Representative Publications

 

Cell Polarity (top)

Reviews

Spiliotis, E. and Nelson, W. J. (2008). Septin functions in the mammalian cytoskeleton.  “Septins” (ed. H. Harris). in press.

Hunt, V. S. and Nelson. W. J. (2006). Protein sorting in the exocytic and endocytic pathways in polarized epithelial cells. In: Physiology of the Gastrointestinal Tract. Ed. K. Barrett, 4th Edition, pp. 1595-1625.

Spiliotis, A. and Nelson, W. J. (2006). Here come the septins: novel polymers that control intracellular organization and functions. J. Cell Science. 119, 4-10.

Nelson, W. J. (2004). A cellular choreographer [News & Views]. Nature. 428, 28-29.

Nelson, W. J. (2003). Tube morphogenesis: closure, but many openings remain. Trends Cell Biol. 13, 615-621.

Nelson, W. J. (2003). Adaptation of core mechanisms to generate cell polarity. Nature. 422, 766-774.

Krasnow, M. and Nelson, W. J. (2002). Tube Morphogenesis. Trends Cell Biol. 12, 251.

Nelson, W. J. and Rodriguez-Boulan, E. (2004). Unravelling protein sorting [News & Views]. Nature Cell Biol. 6, 282-284.

Spiliotis, E. and Nelson, W. J. (2003). Spatial control of exocytosis. Curr. Op. Cell Biol. 15, 430-437.

Nelson, W. J. (2003). Mum, this bud's for you: where do you want to put it? (Roles for Cdc42 in controlling bud site selection in Saccharomyces cerevisiae). BioEssays, 25, 833-836.

Nelson, W. J. (2003). Epithelial cell polarity from the outside looking in. News Physiol. Sci. 18, 143-146.

Yeaman, C., Grindstaff, K. K., and Nelson, W. J. (1999). New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol. Review. 79, 73-98.

Drubin, D. and Nelson, W. J. (1996). Origins of cell polarity. Cell 84, 335-344.

Mays R. W., W. J. Nelson and Marrs J. A. (1995). E-cadherin-mediated cell adhesion as a determinant of epithelial cell polarity: generation of positional information for cytoskeleton organization and vesicle targeting. Cold Spring Harbor Symp. Quant. Biol. LX, 763-773.

Research

Spiliotis, E., Hunt, V. S., Hu, Q., Kinoshita, M. and Nelson, W. J. (2008) Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J. Cell Biol., in press

Hunt, V. S. and Nelson, W. J. (2007). Fabrication of a dual substrate display to test roles of cell adhesion proteins in vesicle targeting to plasma membrane domains. FEBS. Lett., 581, 4539-4543.

Sääf, A. M., Halbleib, J. M., Chen, X., Yuen, S. T., Leung, S. Y., Nelson, W. J. and Brown, P. O. (2007). Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal and colon cancer. Mol. Biol. Cell.18, 4245-4260.

Halbleib, J. M., Sääf, A. M., Brown, P. O. and Nelson, W. J. (2007). A switch in global gene expression programs during development of a polarized epithelium in vitro. Mol. Biol. Cell. 18, 4261-4278.

Nejsum, L. and Nelson, W. J. (2007). A molecular mechanism directly linking E-cadherin adhesion to development of epithlelial cell surface polarity. J. Cell Biol. 178, 323-335.

Spiliotis, E., Kinoshita, M. and Nelson, W. J. (2005). A mitotic septin scaffold required for mammalian chromosome congression and segregation. Science. 307, 1781-1785.

Yeaman, C., Ayala, M. I., Wright, J. R., Bossard, C., Bard, F., Ang, A., Maeda, Y, Seufferlein, T., Mellman, I., Nelson, W. J. and Malhotra, V. (2004). Protein kinase D (PKD) regulates basolateral protein exit from the trans-Golgi Network. Nature Cell Biol. 6, 106-112.

Yeaman, C., Grindstaff, K. K., and Nelson, W. J. (2004). Mechanism of Sec6/8 (exocyst) complex localization to the apical junctional complex during polarization of epithelial cells. J. Cell Sci, 117, 559-570.

Müsch, A., Cohen, D., Yeaman, C., Nelson, W. J., Rodriguez-Boulan, E. and Brennwald, P. J. (2002). A mammalian homologue of the Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in MDCK cells. Mol. Biol. Cell. 13, 158-168.

Yeaman, C, Grindstaff, K. K., Wright, J. R and Nelson, W. J. (2001). Sec6/8 complexes on TGN and plasma membrane regulate late stages of exocytosis in mammalian cells. J. Cell Biol. 155, 593-604.

Matern, H. T., Yeaman, C., Nelson, W. J. and Scheller, R. H. (2001). The sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Proc. Natl. Acad. Sci. USA. 98, 9648-9653.

Jou, T-S., Leung S-M., Fung, L. M., Ruiz, W. G., Nelson W. J. and Apodaca, G. (2000). Roles of the small GTPase Rac1 in biosynthetic and endocytic trafic in polarized MDCK epithelial cells. Mol. Biol. Cell 11, 287-304.

Grindstaff, K. K., Yeaman, C., Anandasabapathy, N., Hsu, S-C., Rodriguez-Boulan, E., Scheller, R. H., and Nelson, W. J. (1998). Sec 6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in polarized epithelial cells. Cell 93, 731-740.

Grindstaff, K. K., Bacallao, R. L., and Nelson, W. J. (1998). Role of microtubule organization in protein delivery to specific membrane domains during the establishment of polarity in epithelial cells. Mol. Biol. Cell 9, 685-699.

Ojakian, G. K., Nelson, W. J., and Beck, K. A. (1997). Mechanisms for de novo biogenesis of an apical membrane compartment in groups of simple epithelial cells surrounded by extracellular matrix. J. Cell Sci. 110, 2781-2794.

 

Cell-Cell Adhesion (top)

Reviews

Hartsock A., and Nelson W. J. (2008). Adherens junctions and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim. Biophys. Acta. In press

Benjamin, J. and Nelson, W. J. (2008). Bench to bedside and back again: Molecular functions of a-catenin and roles in cancer. Sem Cancer Biol. 18, 53-64.

Kwiatkowski, A., Weis, W. I.  and Nelson, W. J. (2007). Catenins: playing both sides of the synapse. Curr. Opin. Cell Biol. 19, 551-556.

Yamada, S. and Nelson, W. J. (2007). Synapses - Sites of cell recognition, adhesion and functional specification. Annual Rev. Biochemistry, 76, 267-294

Weiss, W. I. and Nelson, W. J. (2006). Re-solving the cadherin-catenin-actin conundrum. J. Biol. Chem. 281, 35593-35597.

Halbleib, J. M. and Nelson, W. J. (2006). Cadherins in development: cell Adhesion, sorting and tissue morphogenesis. Genes & Development 20, 3199-3214.

Nathke, I. S. and Nelson ,W. J. (2005). Cell-to-cell contact and extracellular matrix Laying down the rules for proper cell behavior. Curr. Opin. Cell Biol. 17, 443-445.

Cline, E. and Nelson, W. J. (2004). Dual location proteins: Communication between cell adhesions and the nucleus. In: Cell Migration in Development and Disease. (Ed. D. Weidlich, Wiley-HCH). pp. 47-70.

Ehrlich, J. S., Nelson, W. J. and Hansen, M. D. H. (2004). In: Cell Motility: from molecules to organisms (Wiley and Sons) Ed. A Ridley, M. Peckham, P. Clarke. pp 101-116.

Nelson, W. J. and Nusse, R. (2004). Convergence of Wnt, a-catenin and cadherin pathways. Science, 303, 1483-1487.

Vogelmann, R., Amieva, M., Falkow, S., and Nelson, W. J. (2004). Breaking into the epithelial apical junctional complex: news from pathogen hackers. Cur. Opin. Cell Biol. 16, 86-93.

Drees, F. and Nelson, W. J. (2003). Cadherin-mediated cell-cell adhesion. In: Encyclopedia for Biol. Chem., in press.

Perez, T. and Nelson, W. J. (2003). Cadherin adhesion: mechanism and molecular interactions. In: Handbook of Experimental Pharmacology. Cell Adhesion (Ed. J. Behrens, W. J Nelson). in press.

Adams, C. and Nelson, W. J. (1998). Cytomechanics of cadherin-mediated cell-cell adhesion. Cur. Opin. Cell Biol. 10, 572-577.

Research

Perez, T., Yamada, M., Sheetz, M. P. and Nelson W. J. (2008). Immediate-early signaling events induced E-cadherin cell-cell adhesion. J. Biol. Chem., in press

Yamada, S. and Nelson, W. J. (2007). Localized Rho activation regulates actomyosin contraction and compaction of epithelial cell-cell adhesion. J. Cell Biol. 178, 517-527.

Tamada, M., Perez, T., Nelson W. J. and Sheetz, M. P. (2007). Recruitment and activation of the myosin contractile ring at the tight junction during epithelial wound closure. J. Cell Biol. 176, 27-33.

Vogelmann, R and Nelson W. J. (2007). Separation of cell-cell adhesion complexes by differential centrifugation. Methods in Molecular Biology. (Ed. Coutts A. S.) 370, pp. 11-22

Wodarz, A. Stewart, D. A. Nelson, W. J. and Nusse, R. (2006). Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells. J. Cell Science. 119, 2425-2435.

Yamada, S, Drees, F, Pokutta, S., Weis, W. I., and Nelson, W. J. (2005). Deconstructing the cadherin-catenin-actin complex. Cell. 123, 889-901.

Drees, F., Pokutta, S., Yamada, S., Nelson, W. J., and Weis, W. I. (2005). Alpha-catenin is a molecular switch that binds E-cadherin/b-catenin and regulates actin filament assembly. Cell. 123, 903-915.

Perez, T. D., Nelson, W. J., Boxer, S. G. and Kam. L. (2005) Epithelial cell clustering of E-cadherin tethered to micropatterned supported lipid bilayers. Langmuir. 21, 11963-11968.

Nelson, W. J., Drees, F. and Yamada, S. (2005) Interaction of cadherin with the actin cytoskeleton. Novartis Found. Symp. 269, 159-168.

Vogelmann, R. and Nelson W. J. (2005). Fractionation of the epithelial apical junctional complex: reassessment of protein distributions in different sub-structures. Mol. Biol. Cell. 16, 701-716.

Drees, F., Reilein, A. and Nelson, W. J. (2004). Cell adhesion assays: fabrication of an E-cadherin substratum and isolation of lateral and basal membrane patches. In: Methods in Molecular Biology: Cell Migration in Development. (Ed. Jun-Lin Guan, Humana Press) 294, 303-320.

Amieva, M. Vogelmann, R., Covacci, A., Tomkins, L. C., Nelson, W. J., and Falkow, S. (2003). Helicobacter pylori CagA targets and disrupts the epithelial apical junctional complex. Science 300, 1430-1434.

Ehrlich, J. S., Hansen, M. D. H., and Nelson. W. J. (2002). Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Developmental Cell, 3, 259-270.

Hansen, M. D. H., Ehrlich, J. S. and Nelson. W. J. (2002). Molecular mechanism for orienting membrane and actin dynamics to nascent epithelial cell-cell contacts. J. Biol. Chem. 277, 45371-45376.

Pokutta, S., Drees, F., Takai, Y., Nelson, W. J., Weis, W. (2002). Biochemical and structural definition of the L-afadin and actin binding domains of a-catenin. J. Biol. Chem. 277, 18868-18874.

Huber, A. H., Stewart, D. B., Laurents, D. V., Nelson, W. J., and Weis, W. I. (2001). The cadherin cytoplasmic domain is unstructured in the absence of a-catenin: a possible mechanism for regulating cadherin turnover. J. Biol. Chem. 276, 12301-12309.

Hansen, M. D., and Nelson, W. J. (2001). Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex. Current Biol. 11, 356-360.

Stewart, D., Barth, A, I. M., and Nelson, W. J. (2000). Differential regulation of endogenous cadherin expression in MDCK cells by cell-cell adhesion and activation of b-catenin signaling. J. Biol. Chem., 275, 20707-20716.

Troxall, M. L., Gopalakrishnan, S., McCormick,, C., Poteat, B. A., Pennington, J., Garringer, S. M., Schneeberger, E., Nelson, W. J. and Marrs, J. A. (2000). Cadherin function during dynamic junctional complex rearrangement, and post-translational control of cadherin expression levels. J. Cell Sci. 113

Barth, A. M., Stewart, D. B., and Nelson, W. J. (1999). T cell factor-dependent transcription is not sufficient to induce anchorage-independent growth of normal epithelial cells expressing mutant b-catenin. Proc. Natl. Acad. Sci. USA 96: 4947-4952.

Chen, Y-T., Stewart D. B., and Nelson W. J. (1999) Coupling assembly of the E-cadherin/b-catenin complex to efficient ER exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells J. Cell Biol. 144, 687-699.

Adams, C.A., Chen, Y-T., Smith S. J, and Nelson, W. J. (1998). Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high resolution tracking of E-cadherin/GFP. J. Cell Biol. 142, 1105-1119.

Jou, T-S., and Nelson, W. J. (1998). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142, 85-100.

Jou, T-S, Schneeberger, E., and Nelson, W. J. (1998). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142, 101-115.

Higgins, J. M. G., Mandlebrot, D. A., Shaw, S. K., Russell, G. J., Murphy, E. A., Chen, Y-T., Nelson, W. J., Parker, C. M., Brenner, M. B. (1998). Direct and regulated interaction of integrin aEb7 with E-cadherin. J. Cell Biol. 140, 197-210.

Stewart, D. B. and Nelson, W. J. (1997). Identification of four distinct pools of catenins in mammalian cells and transformation-dependent changes in catenin distributions between these pools. J. Biol. Chem. 272, 29652-29662.

Huber, A. H., Nelson, W.J., and Weis, W. I. (1997). Three-dimensional structure of the armadillo repeat of a-catenin. Cell 90, 871-882.

Adams, C. A., Nelson, W. J., and Smith, S J. (1996). Quantitative, single-cell analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion. J. Cell Biol. 135, 1899-1911.

Angres, B. A., Barth, A., and Nelson, W. J. (1996). Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay. J. Cell Biol. 134: 549-558.

 

Kidney Physiology (top)

Reviews

Piepenhagen, P. A., and Nelson, W. J. (1999). Intra- and intercellular localization of proteins in tissue in situ. In: "Signaling through cell adhesion molecules", J-L. Guan, Ed. CRC Press, pp. 84-103.

Research

Vogelmann, S. U., Nelson, W. J., Myers, B. D., Lemley, K. V. (2003). Urinary excretion of viable podocytes in health and renal disease. Amer. J. Physiol. 285, F40-F48.

Kwon, O., Corrigan, G., Myers, B. D., Sibley, R., Scandling, J. D., Dafoe, D., Alfrey, E., and Nelson, W. J. (1999). Sodium reabsorption and distribution of Na/K-ATPase during postischemic injury to the renal allograft. Kid. International 55, 963-975.

Kwon, O., Myers, B. D., Sibley, R., Dafoe, D., Alfrey, E., and Nelson, W. J. (1998). Distribution of cell membrane associated proteins along the human nephron. J. Histochem. Cytochem. 46, 1423-1434.

Piepenhagen, P. A. and Nelson, W. J. (1998). Biogenesis of polarized epithelial cells during kidney development in situ: Roles of E-cadherin-mediated cell-cell adhesion and membrane cytoskeleton organization. Mol. Biol. Cell 9, 3161-3177.

Kwon, O., Nelson, W. J., Sibley, R., Huie, P., Scandling, J. D., Dafoe, D., Alfrey, E., and Myers, B. D. (1998). Backleak, tight junctions, and cell-cell adhesion in postischemic injury to the renal allograft. J. Clin. Invest. 101, 2054-2064.

Alejandro, V. S. J., Nelson, W. J., Huie, P., Sibley, R. K. Dafoe, D., Kuo, P., Scandling, J. D. and Myers, B. D. (1995). Postischemic injury, delayed function and Na/K-ATPase distribution in the transplanted kidney. Kidney Int. 48, 1308-1315.

Piepenhagen, P. A. and Nelson, W. J. (1995). Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron. Am. J. Physiol. Cell 38: C1433-1449.

Piepenhagen, P. A., Peters L. L., Lux S. E., and Nelson, W. J. (1995). Differential expression of Na/K-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron. Am. J. Physiol. Cell 38, C1417-C1432.

Avner, E. D., Sweeney, B. E., Nelson, W. J. (1992). Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease. Proc. Natl. Acad. Sci. (USA), 89, 7447-7451.

 

APC/Microtubules (top)

Reviews

Bahmanyar, S., Nelson, W. J. and Barth A. I. M. (2008) Role of APC and its binding partners in regulating microtubules in mitosis. In: APC Proteins (Eds. Näthke, I. and McCartney, B.). In press.

Votin, V., Nelson, W. J. and Barth A. I. M. (2006). The role of APC complexes and the microtubule cytoskeleton in neuronal morphogenesis. In: Protein Trafficking in Neurons (Ed. Bean, A) pp. 45-59.

Barth, A. I. M. and Nelson, W. J. (2002). What can humans learn from flies about adenomatous polyposis coli? BioEssays. 9, 771-774.

Barth, A. I. M., Nathke, I, and Nelson, W. J. (1997). Cadherins, catenins and APC protein: interplay between cytoskeletal and signaling pathways. Curr. Opinion. Cell Biol. 9, 683-690.

Research

Bahmanyar, S., Kaplan, D. D., Deluca, J. G., Giddings, T. H., O’Toole, E. T., Winey, M., Salmon, E. D., Casey, P. J., Nelson, W. J., Barth, A. I. M. (2008). b-catenin is a Nek2 substrate involved in centrosome separation. Genes & Development 22, 91-105

Reilein, A. Yamada, S., and Nelson, W. J. (2005). Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells. J. Cell Biol. 171, 845-855.

Votin, V., Nelson, W. J. and Barth, A. I. M. (2005). Neurite outgrowth involves adenomatous polyposis (APC) protein and b-catenin. J. Cell Science. 118, 5699-5708.

Reilein, A. and Nelson, W. J. (2005). Adenomatous polyposis coli protein is a component of an organizing template for cortical microtubule networks. Nature Cell Biol. 5, 463-473.

Louie., R. K., Bahmanyar, S., Siemers, K. A., Votin, V., Chang, P., Stearns, T., Nelson, W. J., and Barth, A. I. M. (2004). Adenomatous Polyposis Coli (APC) and EB1 localize to the mother centriole and are functional components of mammalian centrosomes. J. Cell Sci, 117, 1117-1128.

Barth, A. I. M., Siemers, K., and Nelson, W. J. (2002). Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane. J. Cell Sci, 115, 1583-1590.

Pollack, A. L., Barth, A. I. M., Altschuler, Y., Nelson, W. J. and Mostov, K. E.(1997). Dynamics of b-catenin interactions with APC protein regulate epithelial tubulogenesis. J. Cell Biol. 137, 1651-1662.

Barth, A. I. M., Pollack, A. L., Altschuler, Y., Mostov, K. E., and Nelson, W. J. (1997). NH2-terminal deletion of catenin results in stable co-localization of mutant b-catenin with APC protein and altered MDCK cell adhesion. J. Cell Biol. 136, 693-706.

Näthke I. S., Adams C. L., Polakis P., Sellin J. H., and Nelson W. J. (1996). The Adenomatous Polyposis Coli (APC) tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134, 165-180.

 

Membrane Cytoskeletons (top)

Reviews

Nelson, W. J., Wilson, R., Wollner, D. A., Mays, R., McNeill, H., Siemers, K. A. (1992). Regulation of epithelial cell polarity: a view from the cell surface. Cold Spring Harbor Laboratory Symp. in Quant. Biol. LVII 621-630.

Reviews

Mays, R. W., Siemers, K. A., Fritz, B. A., Lowe, A. W., van Meer, G. and Nelson, W. J. (1995). Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells. J. Cell Biol. 130, 1071-1080.

Marrs, J. A., Andersson-Fisone, C., Jeong, M., Nabi, I. V., Zurzolo, C., Rodriguez-Boulan, E, and Nelson, W. J. (1995). Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J. Cell Biol. 129, 507-519.

Beck, K. A., Malhotra, V. and Nelson, W. J. (1994). Golgi spectrin: identification of an erythroid beta-spectrin homologue associated with the Golgi complex. J. Cell Biol., 127, 707-723.

Marrs, J. A., Napolitano, E, Erdosh-Murhy, C., Mays, R. W., Reichardt, L. and Nelson, W. J. (1993). Distinguishing roles of the membrane-cytoskeleton and cadherin-mediated cell-cell adhesion in generating different Na/K-ATPase distributions in polarized epithelia. J. Cell Biol. 123, 149-164.

Siemers, K. A., Wilson, R., Mays, R., Ryan, T., Wollner, D. A. and Nelson, W. J. (1993). Delivery of Na/K-ATPase in polarized epithelial cells. Science 260, 554-556.

Hammerton, R. W., Krzeminski, K. A., Mays, R. W., Ryan, T. A., Wollner, D. A., Nelson, W. J. (1991). Mechanism for regulating cell surface distribution of Na/K-ATPase in polarized epithelial cells. Science, 254, 847-850.

McNeill, H., Ozawa, M., Kemler, R., and Nelson, W. J. (1990). Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell 62, 309-316.

 

What others say about our research (top)

What Others (at least publicly) say about our papers

1. Perez, T. D,, Tamada, M., Sheetz, M. P. and  Nelson, W. J. (2008). Immediate-early signaling induced by E-cadherin engagement and adhesion. J. Biol. Chem. In press

2. Spiliotis, E., Hunt, V. S. and Nelson, W. J. (2008). Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J. Cell Biol. in press

  1. In This Issue, Journal of Cell Biology

3. Tamada,  M., Perez,  T. D., Nelson, W. J. and Sheetz, M. P. (2007). Recruitment and activation of a myosin contractile ring at tight junctions during epithelial wound closure. J. Cell Biol. 176, 27-33

  • Faculty of 1000; Must Read

http://www.f1000biology.com/article/id/1066001/evaluation

4. Nejsum, L and Nelson, W. J. (2007). A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity. J. Cell Biol.. 178, 323-335.

  1. Faculty of 1000: Must Read

http://www.f1000biology.com/article/id/1088658/evaluation

  1. Editors’ Choice: Highlights of Research Literature: “Organizer without an organizer”. Science, 317: 572 (2007).
  1. Cover, Journal of Cell Biology Vol 178, no. 2
  1. In This Issue, Journal of Cell Biology

Polarizing power of touch, J. Cell Biol. 178: 180 (2007)

  1. Research Highlight, Nature Reviews in Molecular Cell Biology

Cell polarity: Acquiring direction from new contacts. Nat. Rev. Mol. Cell Biol. 8: 678 (2007

 

5. Yamada, S. and Nelson, W. J. (2007). Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J. Cell Biol.. 178, 517-527.

  1. Faculty of 1000; Must Read

http://www.f1000biology.com/article/id/1089749/evaluation

6. Saaf, A., Halbleib, J. M., Chen, X., Yuen, S. T, Leung, S. Y., Nelson, W. J., and Brown, P. O. (2007). Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol. Biol Cell. 18, 4245-4260.

Halbleib, J. M., Saaf, A., Brown, P. O. and Nelson, W. J. (2007). A switch in global transcriptional programs during development of epithelial cell polarity in vitro.  Mol. Biol. Cell. 18, 4261-4278.

  1. InCyte from MBC (ASCB Newsletter) Vol. 18, #11

http://www.ascb.org/files/0711incytes.pdf

7. Tamada,  M., Perez,  T. D., Nelson, W. J. and Sheetz, M. P. (2007). Recruitment and activation of a myosin contractile ring at tight junctions during epithelial wound closure. J. Cell Biol. 176, 27-33

  • Faculty of 1000; Must Read

http://www.f1000biology.com/article/id/1066001/evaluation

8. Yamada, S, Drees, F, Pokutta, S., Weis, W. W., and Nelson, W. J. (2005). Deconstructing the cadherin-catenin-actin complex. Cell 123, 889-901

Drees, F., Pokutta, S., Yamada, S., Nelson, W. J., and Weis, W. W. (2005). a-catenin is a molecular switch that binds E-cadherin/b-catenin and regulates actin filament assembly. Cell 123, 903-915.

  1. Minireview. “Can 1000 reviews be wrong? Actin, a-catenin, adherens junctions.” Gates, J. and Peifer, M. Cell, 123: 769-772 (2005).
  1. Research Roundup. “Virtual adherens junction”, Journal of Cell Biology, 172: 4 (2006).
  1. Noteworthy contribution to the scientific literature. “Complex Interactions at the Adherens Junction”. Science STKE, 313: ppt435 (2005) (http//Stke.sciencemag.org/content/vol2005/issue313/#STKE_TWIST).
  1. Research Highlights: “a-catenin: static or dynamic?” Nature Reviews Molecular Cell Biology, 7: 18 Jan published online (2006)

(www.nature.com/nrm/journal/vaop/ncurrent/full/nrm1852.html).

5.      News and Views: “ A break in the chain”. Burridge, K. Nature, 440: 38-39 (2006).

  1. Faculty of 1000: Designated as Exceptional Broad Impact Papers: http://www.f1000biology.com/article/id/1029479/evaluation

http://www.f1000biology.com/article/id/1014087/evaluation

9. Reilein, A., Yamada, S., and Nelson, W. J. (2005). Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells.  J. Cell Biol. 171, 845-855.

  1. Editors’ Choice: Highlights of Research Literature: “Organizer without an organizer”. Science, 310: 1871 (2006).

 

  1. Highlights in this Issue: “Centrosome-free basal MT organization.” Journal of Cell Biology 171: 754 (2006).

9. Votin, V., Nelson, W. J. and Barth, A. I. M. (2005). Neurite outgrowth involves adenomatous polyposis (APC) protein and b-catenin. J. Cell Science 118, 5699-5708.

  1. Faculty of 1000. Recommended

http://www.f1000biology.com/article/id/1029758/evaluation

10. Perez, T. D., Nelson, W. J., Boxer, S. G. and Kam. L. (2005) Epithelial cell clustering of E-cadherin tethered to micropatterned supported lipid bilayers.  Langmuir, 21, 11963-11968.

  1. Faculty of 1000. Recommended

http://www.f1000biology.com/article/id/1029496/evaluation

11. Spiliotis, E., Kinoshita, M. and Nelson, W. J. (2005). A mitotic septin scaffold required for mammalian chromosome congression and segregation. Science 307, 1781-1785.

  1. Faculty of 1000. Recommended

http://www.f1000biology.com/article/id/1024394/evaluation

12. Amieva, M. Vogelmann, R., Covacci, A., Tomkins, L. C., Nelson, W. J. and Falkow, S. (2003). Helicobacter pylori CagA targets and disrupts the epithelial apical junctional complex.  Science, 300, 1430-1434.

  1. Faculty of 1000. Must Read

http://www.f1000biology.com/article/id/1008559/evaluation

13. Ehrlich, J. S., Hansen, M. D. H. and Nelson. W. J. (2002). Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Developmental Cell, 3, 259-270.

  1. Faculty of 1000. Recommended

http://www.f1000biology.com/article/id/1009554/evaluation
 
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